Low dose Naltrexone will release hormones called endorphins in the body over a long period of time. The endorphins will help in mitigating the inflammation, which lies at the root of various MS symptoms. Researchers continue to study the beneficial effects of LDN for multiple sclerosis, and the initial findings have shown significant promise.
Until now the research related to the efficacy of LDN for relieving multiple sclerosis symptoms has only been limited. However, several studies are in progress to determine a correlation between the two. In any case, anecdotal evidence from many patients who are living with the symptoms of multiple sclerosis suggests a positive response of LDN to this condition.
Some other patients have said that after taking LDN, the progression of their condition appeared to have slowed down. Until I reached 2.
Once I got to 3 mg, however, I noted the commonly reported side effect of rather peculiar dreams. Rather, they were out-of-the-ordinary for me dreams, seen in letterbox fashion like the wide-screen versions of films when shown on television. It could be said — and was said by my wife, Caryn — that I may have been uncharacteristically snappy for a few weeks as I got used to the effects of my final dose. I also felt that while my emotional troughs were a little less deep, the good parts — the peaks — were a little less high.
It was as if the waves of my emotions had been squashed, both bottom and top. Instead, it's because this is an inexpensive medicine that's been on the market for decades, meaning pharmaceutical companies have little financial interest in researching it. In spite of that obstacle, scientists have learned a fair amount about LDN in recent years, and its use as an MS drug has now got a fairly compelling, although still preliminary, body of evidence behind it.
Naltrexone was approved by the U. At the full recommended dose—50 to milligram mg per day—naltrexone blocks the effect of opioids and reduces a person's desire to drink. While these are the only two FDA-approved uses for the drug, it is used for several other health issues in an off-label capacity. At the time naltrexone was first developed, researchers at the Penn State College of Medicine began studying its use in treating autoimmune disorders where the immune system mistakenly attacks the body's own cells.
Multiple sclerosis is believed to be an autoimmune disease, with the immune system attacking and destroying the myelin coating of nerve fibers, impeding nerve functioning. This drug is not considered a disease-modifying therapy. The suspected effect of LDN is similar to what occurs during pregnancy, in which increased endorphin levels lead to extended MS remissions. In addition, it's been proposed as a treatment for multiple other conditions, including:. Researchers are beginning to understand the mechanisms of action in LDN, which are significantly different from that of full-strength naltrexone.
LDN is made up of two molecules. One of the molecules, dextro-naltrexone, binds to immune cells. The other, levo-naltrexone, attaches itself to opioid receptors. These actions are dose-dependent, meaning they happen in low doses but not higher ones. The result of those molecular attachments includes several mechanisms that may lead to improvements in MS symptoms, including:. A review of LDN research published in noted several beneficial outcomes from peer-reviewed studies using the drug to treat MS, including:.
However, not all results have been positive or consistent. The review cited:. LDN is most commonly taken in pill form. Liquid sublingual under the tongue and transdermal through the skin forms are also available.
The dosages commonly prescribed in people with MS range from 1. It is approved by the U. Download Brochure. Learn More. Watch Video. Download Document.
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